Акапатамаб

Acapatamab

МНН

Rec. INN (зарегистрированное ВОЗ)

Химическое название

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens FOLH1 (folate hydrolase, prostate specific membrane antigen, PSMA)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific;
IG single chain scFv-scFv-scFc, anti FOLH1 and anti-CD3E (1-986) [scFv-VH-Vkappa anti-FOLH1 (1-243) [VH (Homo sapiens IGHV3-11*01 G49>C (44) (84.7%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -15-mer-tris(tetraglycyl-seryl) linker (122-136)-V-KAPPA (Homo sapiens IGKV1-16*01 (79.3%) -IGKJ2*01 Q120>C (236) (90.9%)) CDR-IMGT [6.3.9] (163-168.186-188.225-233) (137-243)] -6-mer seryl-tetraglycyl-seryl linker (244- 249) -scFv-VH-V-lambda anti-CD3E (250-498) [VH (Mus musculus IGHV10- 1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87.0%) - (IGHD) -IGHJ5*01 (100%)) CDR-IMGT [8.10.16] (275-282.300-309.348-363) (250-374) -15-mer-tris(tetraglycyl-seryl) linker (375-389) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%)) CDR-IMGT [9.3.9] (415- 423.441-443.480-488) (390-498)] -4-mer- tetraglycyl linker (499-502) -scFc (hCH2-CH3)-(h-CH2-CH3) (503-986) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (503-512), CH2 R83>C (574), N84.4>G (579), V85>C (584) (513-622), CH3 E12 (638), M14 (640) (623-727), CHS (728-729)) (503-729) -30- mer hexakis(tetraglycyl-seryl) linker (730-759) -Homo sapiens IGHG1*03 hCH2-CH3, nG1m1 (hinge 6-15 (760-769), CH2 R83>C (831), N84.4>G (836), V85>C (841) (770-879), CH3 E12 (895), M14 (897) (880-984), CHS (985-986)) (760-986)]], non-glycosylated, produced in Chinese hamster ovary (CHO) cells immunomodulator, antineoplastic

Структура

Структура Акапатамаб

Иностранные названия

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