Акасунлимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2253937-12-9

immunoglobulin G1-lambda/kappa, anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)], and anti-[Homo sapiens TNFRSF9 (tumor necrosis factor receptor (TNFR) superfamily member 9, 4-1BB, CD137)], humanized and Homo sapiens monoclonal antibody, bispecific;
gamma1 heavy chain anti-CD274 humanized (1-450) [VH anti-CD274 humanized (Homo sapiens IGHV3-23*01 (87.6%) -(IGHD) -IGHJ1*01 (100%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1, G1v41 CH2 F1.3, E1.2 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>F (238), L1.2>E (239), D27>A (269) (235-344), CH3 E12 (360), M14 (362), F85.1>L (409) (345-449), CHS K>del (450)) (122-450)], (224-213')-disulfide with lambda light chain anti-CD274 Homo sapiens (1'-214') [V-LAMBDA (Homo sapiens IGLV3-21*02 (97.9%) -IGLJ2*01 (100%)) CDR-IMGT [6.3.11] (26-31.49-51.88-98) (1'-108') -Homo sapiens IGLC2*01 (100%) (109'-214')];
gamma1 heavy chain anti-TNFRSF9 humanized (1''-446'') [VH anti-TNFRSF9 humanized (Homo sapiens IGHV3-49*04 (86%) -(IGHD) -IGHJ2*01 (92.9%)) CDR-IMGT [8.7.11] (26-33.51-57.96-106) (1''-117'') -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (214) (118''-215''), hinge 1-15 (216''-230''), CH2 L1.3>F (234), L1.2>E (235), D27>A (265) (231''-340''), CH3 E12 (356), M14 (358), K88>R (409) (341''-445''), CHS K>del (446)) (118''-446'')], (220''-217''')-disulfide with kappa light chain anti-TNFRSF9 humanized (1'''-217''') [V-KAPPA anti-TNFRSF9 humanized (Homo sapiens IGKV1-33*01 (85.7%) -IGKJ1*01 (90%)) CDR-IMGT [6.3.12] (27-32.50-52.89-100) (1'''-110''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (156), V101 (194) (111'''-217''')]; dimer (230-226'':233-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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