Аказиколцепт

Rec. INN (наименование, зарегистрированное ВОЗ)

2270247-50-0

human inducible T-cell co-stimulator ligand (ICOS ligand) N-terminal fragment (1-122) (variant (N⁵²>H, N⁵⁷>Y, Q¹⁰⁰>R), fused via peptidyl linker ¹²³GGGGSGGGGS¹³² to a human immunoglobulin G1 Fc fragment (133-363) variant (L¹⁵¹>A, L¹⁵²>E, G¹⁵⁴>A, C-terminal K³⁶⁴ deleted), dimer, glycosylated, produced in Chinese hamster ovary (CHO) cells;
[N⁵²>H, N⁵⁷>Y, Q¹⁰⁰>R] human inducible T-cell co-stimulator ligand (ICOS ligand, ICOSL, CD275) N-terminal fragment (1-122) fused via a (G₄S)₂ linker (123-132) to a human immunoglobulin G1 C- terminal K>del Fc fragment (133-363) [Homo sapiens IGHG1*01; hinge 133-147; CH2 148-257 (L151A, L152E, G154A); CH3 258­362; CHS 363], dimer (143-143':146-146')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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