Ацимтамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

DB18674

2738880-26-5

immunoglobulin chain VH-V-kappa-VH'-V-lambda homodimer, anti-[Homo sapiens FCGR3A (Fc gamma receptor IIIa, CD16a)] and anti-[Homo sapiens TNFRSF8 (TNF receptor superfamily member 8, CD30)], monoclonal antibody Homo sapiens and Mus musculus VH-V-kappa-VH'-V-lambda chain non covalent head to tail homodimer, bispecific, tetravalent; IG chain VH-V-kappa-VH'-V-lambda Homo sapiens and Mus musculus (1- 483) [anti-FCGR3A VH (Homo sapiens IGHV1-46*01 (98.0%) -(IGHD) - IGHJ5*01 (92.3%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -9-mer tris(bisglycyl-seryl) linker (121-129) -anti-TNFRSF8 V-KAPPA (Mus musculus IGKV6-15*01 (93.7%) -(IGHD) -IGKJ1*02 (90.0%) K127>N (236), CDR-IMGT [6.3.9] (156-161.179-181.218-226)) (130-236) -9-mer tris(bisglycyl-seryl) linker (237-245) -anti-TNFRSF8 VH' (Mus musculus IGHV1-4*01 (87.8%) -(IGHD) -IGHJ3*01 (86.7%) L123>T (363), A128>S (368), CDR-IMGT [8.8.16] (271-278.296-303.342-357)) (246-368) -9-mer tris(biglycyl-seryl) linker (369-377) -anti-FCGR3A V-LAMBDA (Homo sapiens IGLV3-9*01 (83.7%) -(IGHD) -IGLJ2*01 (91.7%), CDR-IMGT [6.3.9] (403-408.426-428.465-473)) (378-483)]; homodimer head to tail non covalent, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa

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