Адалимумаб фосимдесонид
Adalimumab fosimdesonideМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2402772-93-2
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA)], Homo sapiens monoclonal antibody, conjugated to a derivative of the glucocorticoid receptor modulator (GRM) desonide (24)(12) via a (cystein-S-yl)acetyl-Gly-Glu link ;
gamma1 heavy chain Homo sapiens (1-450) [VH (Homo sapiens IGHV3-9*01 (93.9%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 D12 (360), L14 (362) (345-449), CHS K>del (450)) (122-450)], (224-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-27*01 (95.8%) -IGKJ2*01 (91.7%) L124>V (104)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (230-230'':233-233'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa; conjugated at the S atoms of the reduced cysteinyl 224, 214', 224'' and 214''' with four 2-{[2-({(2S)-4-carboxy-1-[4-({4-[11β-hydroxy-3,20-dioxo-21-(phosphonooxy)-2'H,16βH-[1,3]dioxolo[4',5':16,17]pregna-1,4-dien-2'α-yl]phenyl}methyl)anilino]-1-oxobutan-2-yl}amino)-2-oxoethyl]amino}-2-oxoethyl (fosimdesonide) groups
gamma1 heavy chain Homo sapiens (1-450) [VH (Homo sapiens IGHV3-9*01 (93.9%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 D12 (360), L14 (362) (345-449), CHS K>del (450)) (122-450)], (224-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-27*01 (95.8%) -IGKJ2*01 (91.7%) L124>V (104)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (230-230'':233-233'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa; conjugated at the S atoms of the reduced cysteinyl 224, 214', 224'' and 214''' with four 2-{[2-({(2S)-4-carboxy-1-[4-({4-[11β-hydroxy-3,20-dioxo-21-(phosphonooxy)-2'H,16βH-[1,3]dioxolo[4',5':16,17]pregna-1,4-dien-2'α-yl]phenyl}methyl)anilino]-1-oxobutan-2-yl}amino)-2-oxoethyl]amino}-2-oxoethyl (fosimdesonide) groups
Структура
Иностранные названия
- Adalimumabum fosimdesonidum (латинское)
- Adalimumab fosimdesonide (английское)
- Adalimumab fosimdesonid (немецкое)
- Adalimumab fosimdésonide (французское)
- Adalimumab fosimdesonida (испанское)
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