Адиманебарт

Prop. INN (наименование, предложенное ВОЗ)

3011838-77-7

immunoglobulin G1-lambda2, anti-[Homo sapiens MUSK (muscle associated receptor tyrosine kinase)], humanized monoclonal antibody, agonist;
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 6-G1v14 CH2 A1.3, A1.2 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239) (235-344), CH3 D12 (360), L14 (362) (345-449), CHS K2>del (450)) (122-450)], (224-217')-disulfide with L-lambda2 light chain humanized (1'-218') [V-LAMBDA (Homo sapiens IGLV8-61*01 (89.7%) -IGLJ2*01 (100%), CDR-IMGT [9.3.12] (26'-34'.52'-54'.91'-102')) (1'-112') -Homo sapiens IGLC2*01 (100%) (C-LAMBDA2) (113'-218')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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