Афимкибарт

Prop. INN (наименование, предложенное ВОЗ)

2911580-96-4

immunoglobulin G1-kappa, anti-[Homo sapiens TNFSF15 (tumor necrosis factor (TNF) superfamily member 15, vascular endothelial cell growth inhibitor, VEGI, VEGI192A, TNF superfamily ligand TL1A)], Homo sapiens monoclonal antibody;
H-gamma1 heavy chain Homo sapiens (1-453) [VH (Homo sapiens IGHV1-18*01 (92.9%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (119), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v14-1 CH2 A1.3, A1.2, A1 (CH1 R120>K (221) (125-222), hinge 1-15 (223-237), CH2 L1.3>A (241), L1.2>A (242), G1>A (244) (238-347), CH3 E12 (363), M14 (365) (348-452), CHS K2>del (453)) (125-453)], (227-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-11*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (233-233'':236-236'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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