Алекстатуг

Rec. INN (наименование, зарегистрированное ВОЗ)

2768264-93-1

immunoglobulin G1-lambda7, anti-[Homo sapiens tumor-restricted extracellular ribonucleoprotein (RNP) complex containing  PABPC1 (polyadenylate-binding protein cytoplasmic 1, PABP1) bound to poly(A)RNA], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-469) [VH (Homo sapiens IGHV3-15*02 (95.0%) -(IGHD) -IGHJ6*04 (85.0%), CDR-IMGT [8.10.31] (26-33.51-60.99-129)) (1-140) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (237) (141-238), hinge 1-15 (239-253), CH2 (254-363), CH3 E12 (379), M14 (381) (364-468), CHS K2>del (469)) (141-469)], (243-215')- disulfide with lambda7 light chain Homo sapiens (1'-216') [V-LAMBDA (Homo sapiens IGLV1-47*01 (93.8%) -IGLJ2*01 (100%), CDR-IMGT [8.3.11] (26'-33'.51'-53'.90'-100')) (1'-110') -Homo sapiens IGLC7*01 (100%) (111'-216')]; dimer (249-249'':252-252'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Format: human monoclonal antibody; Note: human B cell isolated from an adenocarcinoma patient and engineered; Type: IgG1-lambda; Antigen: human human polyadenylate-binding protein family member(s) and poly(A) RNA; HeavyChainClass: Gamma1; HeavyChainLength: 469; LightChainClass: lambda; LightChainLength: 216; HeavyPotentialNGlycos: 320; HeavyConfirmedNGlycos: 320; LightPotentialNGlycos: NONE; LightConfirmedNGlycos: NONE; HeavyCysPositions: 22 98 103 104 109 117 167 223 243 249 252 284 344 390 448; HeavyDisulfidesIntra: 22-98 103-117 104-109 167-223 284-344 390-448; LightCysPositions: 22 89 138 197 215; LightDisulfidesIntra: 22-89 138-197; DisulfidesInterH1H2: 249-249 252-252; DisulfidesInterL1H1: 215-243; DisulfidesInterL2H2: 215-243; HVGermline: Homo sapiens IGHV3-15*02; HJGermline: Homo sapiens IGHJ6*03; HCGermline: Homo sapiens IGHG1*03; VHRange: 1-140; CH1Range: 141-238; HingeRange: 239-253; CH2Range: 254-363; CH3Range: 364-468; CHSRange: 469-469 (K470del); LVGermline: Homo sapiens IGLV1-47*01; LJGermline: Homo sapiens IGLJ2*01; LCGermline: Homo sapiens IGLC7*01; VLRange: 1-110; CLRange: 111-216; LightConfirmedPTM: nterpca 1; CDRKabatH1: KAWMS (31-35); CDRKabatH2: RIKSVTDGETTDYAAPVKG (50-68); CDRKabatH3: SFCCRGGSCPSHDTSYCGGQYKSYYYMDV (101-129); CDRKabatL1: SGSSSNIGSSSVS (23-35); CDRKabatL2: KNNQRPS (51-57); CDRKabatL3: STWDDSLSVRV (90-100);

Поделиться этой страницей