Алисветцел

Rec. INN (наименование, зарегистрированное ВОЗ)

equine allogeneic chondrogenic-induced mesenchymal stromal/stem cells (MSCs), isolated from peripheral blood mononuclear cells (PBMCs) collected from donor horses. The MSCs are selected for by growing the PBMCs in media containing fetal bovine serum (FBS) and dexamethasone. The cells are then expanded in media containing FBS, and prior to differentiation towards chondrocytes by growth in media containing FBS, transforming growth factor beta-3 (TGF-β3) and insulin-like growth factor I (IGF-I).
The final cells have a cobblestone morphology, express cellular surface markers CD90 (≥95%) and CD40 (≥85%) and are negative for MHC class II expression (≤2%). The cells secrete prostaglandin E2 (PGE2) and upregulate the cartilage oligomeric matrix protein (COMP) gene (>2.6 fold). The homogenous adhesion of the cells to cartilage lesions is measured using ex vivo cartilage explants

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