Амиместроцел

Prop. INN (наименование, предложенное ВОЗ)

allogeneic mesenchymal stromal cells (MSC) derived from umbilical cord tissue and Wharton's jelly. The tissue is enzymatically digested, and the cells cultured in a serum-free medium supplemented with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) and then cryopreserved. The cells are positive (≥95%) for the mesenchymal stromal cell surface markers CD10, CD73, CD90, and CD105, and are negative (≤2%) for CD14, CD19, CD31, CD34, CD45 and HLA class II histocompatibility antigen (HLA-DR) gamma chain markers. The cells secrete prostaglandin E2 (PGE2), interleukin 6 (IL-6), hepatocyte growth factor (HGF), transforming growth factor alpha (TGF-α), and can be induced by interferon gamma (IFN-γ) to express indoleamine 2,3- dioxygenase 1 (IDO-1). The cells can be induced to differentiate into adipogenic, osteogenic and chondrogenic lineages in vitro. The cells demonstrate inhibitory effects in an in vitro T lymphocyte proliferation assay

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