Амостомиг

Prop. INN (наименование, предложенное ВОЗ)

2889449-09-4

immunoglobulin G1-lambda, anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3)] and anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], humanized monoclonal antibody, bispecific;
H-gamma1 heavy chain anti-CD47 humanized (1-464) [VH (Homo sapiens IGHV3-23*04 (83.8%) -(IGHD) -IGHJ4*01 (92.3%) L123>T (129), CDR-IMGT [8.10.20] (26-33.51-60.104-123)) (1-134) -Homo sapiens IGHG1*01v, G1m17,1>G1m3,1 CH1 R120, CH3 D12, L14, G1v14 CH2 A1.3, A1.2, G1v74 CH3 C10, G1v32 CH3 W22 (knob) (CH1 R120 (231) (135-232), hinge 1-15 (233-247), CH2 L1.3>A (251), L1.2>A (252) (248-357), CH3 D12 (373), L14 (375), S10>C (371), T22>W (383) (358-462), CHS (463-464)) (135-464)], (237-215')-disulfide with common L-lambda2 light chain humanized (1'-216') [V-LAMBDA (Homo sapiens IGLV8-61*01 (85.6%) -IGLJ2*01 (90.9%), CDR-IMGT [9.3.10] (26'-34'.52'-54'.91'-100')) (1'-110') -Homo sapiens IGLC2*01 (100%) (111'-216')];
H-gamma1 heavy chain anti-CD274 humanized (1''-453'') [VH (Homo sapiens IGHV3-20*01 (92.9%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.8.15] (26''-33''.51''-58''.97''-111'')) (1''-122'') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2, G1v75 CH3 C5, G1v33 CH3 S22, A24, V86 (hole) (CH1 R120>K (219'') (123''-220''), hinge 1-15 K7>G (227''), T8>P (228''), H9>GG (229''-230'') (221''-236''), CH2 L1.3>A (240''), L1.2>A (241'') (237''-346''), CH3 E12 (362''), M14 (364''), Y5>C (355''), T22>S (372''), L24>A (374''), Y86>V (413'') (347''-451''), CHS (452''-453'')) (123''-453'')], (225''-215''')-disulfide with common L-lambda2 light chain humanized (1'''-216''') [V-LAMBDA (Homo sapiens IGLV8-61*01 (85.6%) -IGLJ2*01 (90.9%), CDR-IMGT [9.3.10] (26'''-34'''.52'''-54'''.91'''-100''')) (1'''-110''') -Homo sapiens IGLC2*01 (100%) (111'''-216''')]; dimer (243-232'':246-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa

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