Амтабафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2839531-84-7

humanized immunoglobulin G1-lambda anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)] monomer disulfide bridged to human T-cell surface glycoprotein CD4 extracellular domain 1, engineered to bind human immunodeficiency virus gp120 envelope glycoprotein, fused to an Fc fragment of human immunoglobulin G1;
gamma 1 heavy chain (1-445) [VH (Homo sapiens IGHV3-72*01 -(IGHD) - IGHJ4*01, CDR-Kabat [5.19.14] (31-35.50-68.101-114)) (1-125) -Homo sapiens IGHG1*03 (CH1 R²²²>K (126-223), hinge (224-238), CH2 L²⁴²>A, L²⁴³>A, P³³⁹>S (239-348), CH3 T³⁷⁴>S, L³⁷⁶>A, Y⁴¹⁵>V, H⁴⁴³>R (349-453),
CHS (454-455)) (126-455)], (228-214')-disulfide with lambda light chain (1'-215') [V-LAMBDA (Homo sapiens IGLV7-46*01 -IGLJ3*02, CDR-Kabat [14.7.9] (23'-36'.52'-58'.91'-99')) (1'-109') -Homo sapiens IGLC2*01 (110'- 215')]; human T-cell surface glycoprotein CD4 extracellular domain 1 [mutant L⁵''>Y, S²³''>N, A⁵⁵''>V, I⁷⁶''>P, L⁹⁶''>V, F⁹⁸''>V] (fragment 1''-99''), fused via a 100''GS101'' peptide linker to an Fc fragment of immunoglobulin 1 [Homo sapiens IGHG1*03, hinge (102''-111'', N-terminal EPKSC deleted), CH2 L¹¹⁵''>A, L¹¹⁶''>A, M¹³³''>Y, S¹³⁵''>T, T¹³⁷''>E, P²¹²''>S (112''-221''), CH3 T247''>W
(222''-326''), CHS (327''-328'')) (102''-328'')]; heterodimer (234-107'', 237- 110'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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