Амубарвимаб
AmubarvimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2509447-07-6
Химическое название
immunoglobulin G1-kappa, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV3-66*01 (95.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.7.11] (26-33.51-57.96-106)) (1-117) -Homo sapiens IGHG1*01, G1m17,1, G1v21 CH2 Y15.1, T16, E18 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 M15.1>Y (252), S16>T (254), T18>E (256) (231-340), CH3 D12 (356), L14 (358) (341-445), CHS (446-447)) (118-447)], (220-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ2*01 (100%), CDR-IMGT [7.3.8] (27-33.51-53.90-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
dimer (226-226'':229-229'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa
gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV3-66*01 (95.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.7.11] (26-33.51-57.96-106)) (1-117) -Homo sapiens IGHG1*01, G1m17,1, G1v21 CH2 Y15.1, T16, E18 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 M15.1>Y (252), S16>T (254), T18>E (256) (231-340), CH3 D12 (356), L14 (358) (341-445), CHS (446-447)) (118-447)], (220-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ2*01 (100%), CDR-IMGT [7.3.8] (27-33.51-53.90-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
dimer (226-226'':229-229'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa
Структура
Иностранные названия
- Amubarvimabum (латинское)
- Amubarvimab (английское)
- Amubarvimab (немецкое)
- Amubarvimab (французское)
- Amubarvimab (испанское)
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