Амулирафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2850355-94-9

human signal regulatory protein alpha (SIRPα) fragment, anti- (human CD47, integrin associated protein (IAP)), fused via a (G4S)2 peptide linker to the N-terminus of both heavy chains of a chimeric immunoglobulin G1-kappa anti-(human B-lymphocyte antigen CD20), glycoform alfa;
human signal regulatory protein alpha (SIRP alpha variant V2 extracellular D1 domain, SIRP alpha V2D1) fragment 31-163, comprising the first two extracellular loops of the D1 domain, [N¹¹⁰>A⁸⁰]-variant, anti-(human CD47, integrin associated protein (IAP)) (1-133 in the current sequence) fused via a (G4S)2 peptide linker (134-143) to gamma 1 heavy chain (144-594) [VH (Mus musculus IGHV1-12*01 -(IGHD) -IGHJ1*01, CDR-Kabat [5.17.12] (174-178.193-209.242-253)) (144-264) -Homo sapiens IGHG1*03 (CH1 (265-362), hinge (363-377), CH2 S⁴⁴⁵>A, E⁴⁸⁰>A, K⁴⁸¹>A (378- 487), CH3 (488-592), CHS (593-594)) (265-594)], (367-213')-disulfide with kappa light chain (1'-213') [V-KAPPA (Mus musculus IGKV4-72*01 -IGKJ1*01, CDR-Kabat [10.7.9] (24'-33'.49'-55'.88'- 96')) (1'-106') -Homo sapiens IGKC*01 (107'-213')]; dimer (373- 373'':376-376'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Поделиться этой страницей