Анбенитамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2367012-88-0

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine protein kinase erbB-2, EGFR2, HER2, HER-2, p185cerbB2, NEU, CD340)], humanized monoclonal antibody, biparatopic, tetravalent;
gamma1 heavy chain anti-ERBB2 domain II humanized (1-449) [VH anti-ERBB2 domain II (Homo sapiens IGHV3-66*01 (78.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.12] (26-33.51-58.97-108) (1-119) -Homo sapiens IGHG1*01, G1m7,1, G1v32 CH3 W22 (CH1 K120 (217) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 D12 (358), L14 (360), T22>W (368), K88>A (411) (343-447), CHS (448-449)) (120-449)], (222-214')-disulfide with kappa light chain anti-ERBB2 humanized (1'-214') [V-KAPPA anti-ERBB2 humanized (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (194) (108'-214')];
gamma1 heavy chain anti-ERBB2 domain IV humanized (1''-450'') [VH anti-ERBB2 domain IV (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1''-120'') -Homo sapiens IGHG1*01, G1m7,1, G1v33 CH3 S22, A24, V86 (CH1 K120 (217) (121''-218''), hinge 1-15 (219''-233''), CH2 (234''-343''), CH3 D12 (359), L14 (361) T22>S (369), L24>A (371), F85.1>K (408), Y86>V (410) (344''-448''), CHS (449''-450'')) (121''-450'')], (223''-214''')-disulfide with kappa light chain anti-ERBB2 humanized (1'''-214''') [V-KAPPA anti-ERBB2 humanized (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'''-107''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (194) (108'''-214''')]; dimer (228-229'':231-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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