Анетумаб равтансин
Anetumab ravtansineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB14809
CAS
1375258-01-7
Химическое название
immunoglobulin G1-lambda2, anti-[Homo sapiens MSLN (mesothelin, pre-pro-megakaryocyte-potentiating factor, megakaryocyte potentiating factor, MPF, CAK1)], Homo sapiens monoclonal antibody conjugated to maytansinoid DM4;
gamma1 heavy chain (1-450) [Homo sapiens VH (IGHV5-51*01 (94.90%) -(IGHD)-IGHJ4*01) [8.8.13] (1-120) -IGHG1*01 (CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-216')-disulfide with lambda light chain (1'-217') [Homo sapiens V-LAMBDA (IGLV2-14*01 (95.60%) -IGLJ2*01) [9.3.11] (1'-111') -IGLC2*01 A43>G (155) (112'-217')]; dimer (229-229'':232-232'')-bisdisulfide; conjugated, on an average of 3 lysyl, to maytansinoid DM4 [N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine] via the reducible SPDB linker [N-succinimidyl 4-(2-pyridyldithio)butanoate]
gamma1 heavy chain (1-450) [Homo sapiens VH (IGHV5-51*01 (94.90%) -(IGHD)-IGHJ4*01) [8.8.13] (1-120) -IGHG1*01 (CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-216')-disulfide with lambda light chain (1'-217') [Homo sapiens V-LAMBDA (IGLV2-14*01 (95.60%) -IGLJ2*01) [9.3.11] (1'-111') -IGLC2*01 A43>G (155) (112'-217')]; dimer (229-229'':232-232'')-bisdisulfide; conjugated, on an average of 3 lysyl, to maytansinoid DM4 [N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine] via the reducible SPDB linker [N-succinimidyl 4-(2-pyridyldithio)butanoate]
Структура
Иностранные названия
- Anetumabum corixetanum (латинское)
- Anetumab ravtansine (английское)
- Anetumab ravtansin (немецкое)
- Anétumab ravtansine (французское)
- Anetumab ravtansina (испанское)
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