Анватабарт опадотин

Rec. INN (наименование, зарегистрированное ВОЗ)

2636710-07-9

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at two engineered sites via a stable covalent linker with the microtubule-disrupting agent opadotin; gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR- IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 (CH1 A1.4>F (pAF) (121), K120 (217) (121- 218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS K2>del (449)) (121-449)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229":232-232")- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at C-4 of Phe121 and Phe121'' with two (1Z)-N-{[(13S,16S,19S,20R)-19-[(2S)-butan-2-yl]- 22-{(2S)-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1- methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-20-methoxy-12,18- dimethyl-14,17,22-trioxo-13,16-di(propan-2-yl)-3,6,9-trioxa-12,15,18-triazadocosan-1-yl]oxy}ethanimidoyl (opadotin) groups

Поделиться этой страницей