Аплитабарт

Prop. INN (наименование, предложенное ВОЗ)

2796349-94-3

immunoglobulin M-kappa cyclic pentamer bisdisulfide with the JCHAIN (joining chain of multimeric IgA and IgM), anti-[Homo sapiens TNFRSF10B (TNF receptor superfamily member 10B, death receptor 5, DR5, TNF-related apoptosis-inducing ligand TRAIL receptor 2, TRAILR2, TRAIL-R2, TR-2, CD262)], humanized monoclonal antibody, monospecific, decavalent, agonist;
H-mu heavy chain anti-TNFRSF10B humanized (1-572) [VH (Homo sapiens IGHV3-23*03 (90.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHM*03 (100%) (CH1 (120-223), CH2 (224-335), CH3 (336-441), CH4 (442-552), CHS (553-572)) (120-572)], (133-213')-disulfide with L-kappa light chain anti-TNFRSF10B humanized (1'-213') [V-KAPPA (Homo sapiens IGKV1-13*02 (84.9%) -IGKJ1*01 (100%), CDR-IMGT [6.3.8] (27'-32'.50'-52'.89'-96')) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152'), V101 (190') (107'-213')]; dimer (333-333'':410-410'')-bisdisulfide, 5 [H-mu_L-kappa]2 dimers forming a cyclic pentamer, disulfide 4 x (571''-571), and 1x (571''-15'''':69''''-571)-bisdisulfide with the JCHAIN Y102>A (102'''') (1''''-137''''), produced in a cell line derived from Chinese hamster ovary (CHO) cells, glycoform alfa

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