Азиркитуг

Rec. INN (наименование, зарегистрированное ВОЗ)

2837169-12-5

immunoglobulin G1-kappa, anti-[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-73*01 (84.8%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.10.11] (26-33.51-60.99-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234- 343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with L-kappa light chain humanized (1'- 214') [V-KAPPA (Homo sapiens IGKV3-11*01 (78.9%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') - Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line, derived from the cell line CHO-DUX-B11, lacking the enzyme dihydrofolate reductase (DHFR), and co-expressing the RMD enzyme (GDP-6-deoxy-D- lyxo-4-hexulose reductase), glycoform alfa

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