Бафисонтамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2437210-79-0

immunoglobulin G1-kappa-Fab, anti-[Homo sapiens MET (MET proto-oncogene receptor tyrosine kinase, HGFR, RCCP2, DFNB97)] and anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], Homo sapiens and humanized monoclonal antibody, bispecific;
kappa light chain and gamma1 heavy chain Homo sapiens and humanized anti-MET and anti-EGFR (V-KAPPA-C-KAPPA-VH-CH1-h-CH2-CH3) (1-663) [V-KAPPA Homo sapiens anti-MET (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1-107) -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108-214) -VH humanized anti-EGFR (Homo sapiens IGHV4-61*01 (89.9%) -(IGHD) -IGHJ3*02 (100%), CDR-IMGT [10.7.11] (240-249.267-273.312-322)) (215-333) -Homo sapiens IGHG1*03v G1m3>G1m17, nG1m1 (CH1 R120>K (430) (334-431), hinge 1-15 (432-446), CH2 (447-556), CH3 E12 (572), M14 (574) (557-661), CHS (662-663)) (334-663)],
(436-214''')-disulfide with Fab G1-kappa anti-MET and anti-EGFR Homo sapiens [VH (CH1-hinge) gamma1 heavy chain (1''-220'') anti-MET (Homo sapiens IGHV1-18*01 (96.9%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1''-117'') -Homo sapiens IGHG1*01, G1m17 (CH1 K120 (214) (118''-215''), hinge 1-5 (216''-220'') (118''-220'')], (214''-220''')-disulfide with kappa light chain Homo sapiens anti-EGFR (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-33*01 (95.8%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'''-107''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'''-214''')]; dimer (442-442'':445-445'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa

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