Барзолволимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2438203-51-9

immunoglobulin G1-kappa, anti-[Homo sapiens KIT (KIT proto-oncogene receptor tyrosine kinase, c-kit, c-Kit, SCFR, CD117) extracellular domain], monoclonal antibody;
gamma1 heavy chain (1-445) [VH Musmus/Homsap (Mus musculus IGHV1-76*01 (87.8%) -(IGHD) -IGHJ2*01 (93.3%) L124>V (112)/Homo sapiens IGHV1-2*06 (76.5%) -(IGHD) -IGHJ4*01 (93.3%) L123>T (111), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1, G1v21 CH2 Y15.1, T16, E18, G1v20 CH2 A105 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 L1.3>A (233), L1.2>Q (234), M15.1>Y (251), S16>T (253), T18>E (255), K105>Q (321) (230-339), CH3 D12 (355), L14 (357) (340-444), CHS K>del (445)) (117-445)], (219-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-15*01 (84.2%) -IGKJ1*01 (90.9%) L124>V (104)/Homo sapiens IGKV1-16*01 (81.1%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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