Белудавимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2423016-74-2

immunoglobulin G1-kappa, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-457) [VH (Homo sapiens IGHV1-18*01 (92.9%) -(IGHD) -IGHJ5*01 (92.9%), CDR-IMGT [8.8.20] (26-33.51-58.97-116)) (1-127) -Homo sapiens IGHG1*01, G1m17,1, G1v12 CH2 A1.1, L115, E117, G1v24 CH3 L107, S114 (CH1 K120 (224) (128-225), hinge 1-15 (226-240), CH2 G1.1>A (246), A115>L (340), I117>E (342) (241-350), CH3 D12 (366), L14 (368), M107>L (438), N114>S (444) (351-455), CHS (456-457)) (128-457)], (230-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (93.7%) -IGKJ4*01 (100%), CDR-IMGT [7.3.8] (27-33.51-53.90-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (236-236'':239-239'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa

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