Бенмелстобарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2303884-58-2

immunoglobulin G1-kappa, anti-Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*01 (78.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v66 CH2 A27 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 D27>A (264) (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (82.1%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-S Cell line, glycoform alfa

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