Бесуфетамиг

Prop. INN (наименование, предложенное ВОЗ)

3037124-22-1

immunoglobulin (H-gamma1_L-kappa)_(H-gamma1_L-kappa), anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], Homo sapiens monoclonal antibody, bispecific;
H-gamma1 heavy chain anti-PDCD1 Homo sapiens (1-456) [VH (Homo sapiens IGHV7-4-1*02 (90.8%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (122), CDR-IMGT [8.8.20] (26-33.51-58.97-116)) (1-127) -Homo sapiens IGHG1*03 G1m3, nG1m1 CH1 R120, CH3 E12, M14, 6-G1v59-1 CH2 G1.2, R1.1, 14-G1v72 CH3 D7, E24 (CH1 R120 (224) (128-225), hinge 1-15 (226-240), CH2 L1.2>G (245), G1.1>R (246) (241-350), CH3 L7>D (361), E12 (366), M14 (368), L24>E (378) (351-455), CHS K2>del (456)) (128-456)], (230-214')-disulfide with common L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')];
H-gamma1 heavy chain anti-CD3E Homo sapiens (1''-447'') [VH (Homo sapiens IGHV3-30-5*03 (88.8%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [8.8.11] (26''-33''.51''-58''.97''-107'')) (1''-118'') -Homo sapiens IGHG1*03 G1m3, nG1m1 CH1 R120, CH3 E12, M14, 6-G1v59-1 CH2 G1.2, R1.1, 14-G1v73 CH3 K7, K22 (CH1 R120 (215) (119''-216''), hinge 1-15 (217'', 231''), CH2 L1.2>G (236''), G1.1>R (237'') (232''-341''), CH3 L7>K (352''), E12 (357''), M14 (359''), T22>K (367'') (342''-446''), CHS K2>del (447'')) (119''-447'')], (221''-214''')-disulfide with common L-kappa light chain Homo sapiens (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'''), V101 (191''')) (108'''-214''')]; dimer (236-227'': 239-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa

Поделиться этой страницей