Бетифисолимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2460539-60-8

immunoglobulin G1-kappa, anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)], monoclonal antibody;
gamma1 heavy chain (1-449) [VH Musmus/Homsap (Mus musculus IGHV1-64*01 (84.7%) -(IGHD) -IGHJ2*01 (93.3%) T122>S (113)/Homo sapiens IGHV1-2*02 (79.6%) -(IGHD) -IGHJ4*01 (80.0%) T122>S (113), L123>T (114), V124>L (115), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01, G1m17,1, G1v29 CH2 N84.4>A (CH1 K120 (216) (120-217), hinge 1-15 (218-232), CH2 N84.4>A (299) (233-342), CH3 D12 (358), L14 (360) (343-447), CHS (448-449)) (120-449)], (222-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-5*01 (93.9%) -IGKJ2*01 (100%)/Homo sapiens IGKV4-1*01 (65.3%) -IGKJ2*01 (91.7%) Q120>G (104), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated

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