Бексатамиг

Prop. INN (наименование, предложенное ВОЗ)

2871775-98-1

immunoglobulin (H-gamma1-VH-G1CH1h_L-kappa)_L-kappa-G1hCH2CH3, anti-[Homo sapiens IL3RA (interleukin 3 receptor subunit alpha, interleukin 3 receptor alpha (low affinity), CD123)] and anti-[Homo sapiens NCR1 (natural cytotoxicity triggering receptor 1, NKP46, NKp46, NK cell-activating receptor, LY94, CD335)], humanized monoclonal antibody, bispecific;
[H-gamma1-VH-G1CH1h chain anti-IL3RA and anti-NCR1 humanized (1-861) [H-gamma1 anti-IL3RA [VH (Homo sapiens IGHV5-10-1*04 (82.7%) -(IGHD) -IGHJ6*01 (90.9%) T123>M (115), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 (344-448), CHS K2>del (449) (121-449))] -4-mer-seryl-threonyl-glycyl-seryl linker (450-453) -VH-G1CH1h anti-NCR1 humanized (454-681) [VH (Homo sapiens IGHV1-69*08 (83.7%) -(IGHD) -IGHJ4*01 (92.3%) L123>T (568), CDR-IMGT [8.8.13] (479-486.504-511.551-562)) (454-573) -IGHG1*03 CH1-h (100%), G1m3 CH1 R120 (CH1 R120 (670) (574-671), hinge 1-10 (672-681)) (574-681)];
(676-214')-disulfide with L-kappa light chain anti-NCR1 humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (88.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')];
(223-220'':229-226'':232-229'')-trisdisulfide with the L-kappa-G1hCH2CH3 chain anti-IL3RA humanized (1-447'') [L-kappa anti-IL3RA (1''-220'') [V-KAPPA (Homo sapiens IGKV4-1*01 (90.1%) -IGKJ2*01 (100%), CDR-IMGT [12.3.9] (27''-38''.56''-58''.95''-103'')) (1''-113'') -Homo sapiens IGKC*01 (100%), Km3 A45.1 A45.1 (159''), V101 (197'') (114''-220'')] -G1hCH2CH3 (221''-447'') [Homo sapiens IGHG1*03 h-CH2-CH3-CHS (100%), nG1m1 CH3 E12, M14 (hinge 6-15 (221''-230''), CH2 (231''-340''), CH3 E12 (356''), M14 (358'') (341''-445''), CHS (446''-447''))]], produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-DXB11, glycoform alfa

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