Безетабарт

Rec. INN (наименование, зарегистрированное ВОЗ)

immunoglobulin G1-kappa, anti-[Homo sapiens CD74 (major histocompatibility complex class II invariant chain)], monoclonal antibody, modified at two specific positions with reactive 4-(azidomethyl)-l-phenylalanine residues;
gamma1 heavy chain (1-454) [VH (Homo sapiens IGHV3-30-5*03 (95.9%) -(IGHD) -IGHJ6*01 (93.8%), CDR-IMGT [8.8.16] (27-34.52-59.98-113)) (1-124) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (221) (125-222), hinge 1-15 (223-237), CH2 (238-347), CH3 E12 (363), M14 (365), F85.2>F (pAMF) (411) (348-452), CHS (453-454)) (125-454)], (227-215')-disulfide with kappa light chain (1'-215') [V-KAPPA (Homo sapiens IGKV1-12*01 (92.6%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (28'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (154'), V101 (192') (109'-215')]; dimer (233-233'':236-236'')-bisdisulfide, produced by a cell-free protein expression system based on Escherichia coli lysate, non-glycosylated, substituted at C-4 of the two l-phenylalanyl residues 411 and 411'' with azidomethyl (tazide) groups

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