Бидолейцел

Rec. INN (наименование, зарегистрированное ВОЗ)

allogeneic invariant natural killer T cells (iNKT), isolated from peripheral blood leukapheresis of HLA-A2 positive donors. The iNKT cells are enriched using antibody-specific positive selection, and expanded through a two-step stimulation procedure, initially by co-culture with irradiated peripheral blood mononuclear cells (PBMCs) derived from the same donor and alpha-galactosylceramide (αGalCer), and then by co-culture with αGalCer-pulsed irradiated PBMCs, each in media containing human AB serum and interleukin 2 (IL-2). The final cell substance is >99% iNKTs (CD3 and invariant T cell receptor α chain positive) and are in an activated state (CD25 and CD69 positive). The cells can induce dose-dependent target cell killing of glycolipid-presenting tumour cell lines

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