Бинтрафусп Альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

DB15387

1918149-01-5

immunoglobulin G1-lambda, anti-[human programmed cell death 1 ligand 1 (PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1, CD274)], human monoclonal antibody, fused at the C-terminus of both heavy chains via a peptidyl linker (450-471), to a fragment of the mature human extracellular domain of human TGF-beta receptor type-2 (TGFR-2, TGFBR2, transforming growth factor-beta receptor type II)TGFβ type II receptor (472-607), dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; gamma1 heavy chain fused to TGFR-2 (1-607) [Homo sapiens VH (IGHV3-23*01 -(IGHD) -IGHJ4*01) [CDRKabatH1: SYIMM (31-35); CDRKabatH2: SIYPSGGITFYADTVKG (50-66); CDRKabatH3: IKLGTVTTVDY (99-109)] (1-120) -Homo sapiens IGHG1*03, (CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-449, K450del)) (121-449)], (223-215')-disulfide with lambda light chain (1'-216') [Homo sapiens V-LAMBDA (IGLV2-14*01 - IGLJ1*01) [CDRKabatL1: TGTSSDVGGYNYVS (23-36); CDRKabatL2: DVSNRPS (52-58); CDRKabatL3: SSYTSSSTRV (91-100)] (1'-110') - IGLC1*02 (111'-216')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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