Бизаксофусп

Rec. INN (наименование, зарегистрированное ВОЗ)

1236019-35-4

L-methionyl-human interleukin 4 (IL4) C-terminal fragment (38-129, 2-93 in the current sequence) variant (N³⁸>D²), fused via the peptide linker 94GGNGG98 to human interleukin 4 (IL4) N-terminal fragment (1-37, 99-135 in the current sequence) fused via the peptide linker ¹³⁶ASGG¹³⁹ to Pseudomonas aeruginosa exotoxin A fragment (251-613, 140-485 in the current sequence) engineered variant (³⁶⁴SADVVSLTCPVAAGECA³⁸⁰>N²⁵³, I⁴⁰⁷>V²⁸⁰, G⁵¹⁵>S³⁸⁸, ⁶⁰⁹REDLK⁶¹³>⁴⁸²KDEL⁴⁸⁵), non-glycosylated, produced in Escherichia coli; fusion protein of a circularly permuted human interleukin 4 and an engineered construct of fused Pseudomonas aeruginosa exotoxin A fragments: L-methionyl (1)-[N³⁸>D²]-human interleukin 4 (IL4) C-terminal (38-129)-fragment (2-93) fused via a GGNGG linker (94-98) with the human interleukin 4 (IL4) N-terminal (1-37)-fragment (99-135) and via an ASGG linker (136-139) with the [³⁶⁴SADVVSLTCPVAAGECA³⁸⁰>N²⁵³, I⁴⁰⁷>V²⁸⁰, G⁵¹⁵>S³⁸⁸, ⁶⁰⁹REDLK⁶¹³>⁴⁸²KDEL⁴⁸⁵]-(251-613)-fragment of exotoxin A (Pseudomonas aeruginosa) (140-485), non-glycosylated, produced in Escherichia coli

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