Босеролимаб
BoserolimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
USAN (наименование, принятое к употреблению в США)
CAS
2444297-08-7
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD27 (TNFRSF7, tumor necrosis factor receptor (TNFR) superfamily member 7)], monoclonal antibody;
gamma1 heavy chain (1-446) [VH (Homo sapiens IGHV1-2*02 (79.6%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-213')-disulfide with kappa light chain (1'-213') [V-KAPPA Musmus/Homsap (Mus musculus IGKV4-59*01 (80.9%) -IGKJ4*01 (91.7%) S120>Q (104)/Homo sapiens IGKV3-11*01 (80.0%) -IGKJ2*02 (100%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derivative of the cell line CHO-K1, glycoform alfa
gamma1 heavy chain (1-446) [VH (Homo sapiens IGHV1-2*02 (79.6%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-213')-disulfide with kappa light chain (1'-213') [V-KAPPA Musmus/Homsap (Mus musculus IGKV4-59*01 (80.9%) -IGKJ4*01 (91.7%) S120>Q (104)/Homo sapiens IGKV3-11*01 (80.0%) -IGKJ2*02 (100%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derivative of the cell line CHO-K1, glycoform alfa
Структура
Иностранные названия
- Boserolimabum (латинское)
- Boserolimab (английское)
- Boserolimab (немецкое)
- Bosérolimab (французское)
- Boserolimab (испанское)
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