Ботенсилимаб
BotensilimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16651
CAS
2408310-37-0
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CD152)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV3-21*01 (99.0%) -(IGHD) -IGHJ3*02 (92.9%) M123>L (113)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v8 CH2 D3, L115, E117 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 S3>D (240), A115>L (331), I117>E (333) (232-341), CH3 E12 (357), M14 (359) (342-446), CHS K>del (447)) (119-447)], (221-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (94.8%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV3-21*01 (99.0%) -(IGHD) -IGHJ3*02 (92.9%) M123>L (113)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v8 CH2 D3, L115, E117 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 S3>D (240), A115>L (331), I117>E (333) (232-341), CH3 E12 (357), M14 (359) (342-446), CHS K>del (447)) (119-447)], (221-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (94.8%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Botensilimabum (латинское)
- Botensilimab (английское)
- Botensilimab (немецкое)
- Botensilimab (французское)
- Botensilimab (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Ботенсилимаб: