Бренетафусп

Rec. INN (наименование, зарегистрированное ВОЗ)

2736407-54-6

humanized immunoglobulin anti-(human T-cell surface glycoprotein CD3 epsilon chain) single chain variable fragment (scFv) (1-253) containing the light chain variable (VL) region (1-107), the linker ¹⁰⁸GGGGSGGGGSGGGGSGGGGSGGGS¹³¹ and the heavy chain variable (VH) region (132-253) fused via the peptide linker ²⁵⁴GGGGS²⁵⁸ to a human T-cell receptor beta chain anti-(human HLA- A2 antigen complex with preferentially expressed antigen in melanoma (PRAME) protein) fragment (259-502 in the current sequence) engineered variant (S⁴²⁹>C, C⁴⁴⁷>A, N⁴⁶¹>D), disulfide bridged to a human T cell receptor alpha chain anti-(human HLA-A2 antigen complex with preferentially expressed antigen in melanoma (PRAME) protein) fragment (1-201), engineered variant (T¹⁶³>C), non- glycosylated, produced in Escherichia coli; humanized monoclonal scFv antibody fusion with human T-cell receptor; CDR source: Mus musculus; antigen: human T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e (CD3E); type: Fv-kappa scFv; light chain class: kappa; LV germline: Homo sapiens IGKV1-NL1*01; LJ germline: Homo sapiens IGKJ1*01; VL: 1-107; CDR Kabat L1: RASQDIRNYLN (24-34); CDR Kabat L2: YTSRLES (50-56); CDR Kabat L3: QQGNTLPWT (89-97); linker: 108-131; HV germline: Homo sapiens IGHV3-23*04; HJ germline: Homo sapiens IGHJ4*01; VH: 132-253; CDR Kabat H1: GYTMN (162-166); CDR Kabat H2: LINPYKGVSTYNQKFKD (181- 197); CDR Kabat H3: SGYYGDSDWYFDV (230-242); linker: 254-258; fusion protein: 259-372; T-cell receptor beta chain (CB) variable domain [TRBV19*01-TRBJ2-7*01]; fusion protein: 373-502 (S429C C447A N461D); T-cell receptor beta chain constant domain [TRBC2*01]; mutation: S429C (disulfide with CA); mutation: C447A (removed disulfide); mutation: N461D (natural variant); fusion protein: 1-115; T-cell receptor alpha chain (CA) variable domain [TRAV26.1*01- TRAJ15*02]; fusion protein: 116-201 (T163C); T-cell receptor alpha chain constant domain [TRAC*01]; mutation: T163C (disulfide with CB)

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