Бриквилимаб
BriquilimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2574591-89-0
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens KIT (KIT proto-oncogene, receptor tyrosine kinase, C-Kit, c-kit, SCFR, CD117)], monoclonal antibody;
gamma1 heavy chain (1-447) [VH (Homo sapiens IGHV1-3*01 (87.8%) -(IGHD) -IGHJ6*01 (90.9%) T123>L(112), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117)-Homo sapiens IGHG1*01, G1m17,1, G1v36 CH2 N84.4>Q (CH1 K120 (214) (118-215), hinge 1-15 (216- 230), CH2 N84.4>Q (297) (231-340), CH3 D12 (356),L14 (358) (341-445), CHS (446-447)) (118-447)], (220-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-10*01 (84.8%) - IGKJ2*01 (91.7%) L124>V (108)/Homo sapiens IGKV4-1*01 (80.2%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated
gamma1 heavy chain (1-447) [VH (Homo sapiens IGHV1-3*01 (87.8%) -(IGHD) -IGHJ6*01 (90.9%) T123>L(112), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117)-Homo sapiens IGHG1*01, G1m17,1, G1v36 CH2 N84.4>Q (CH1 K120 (214) (118-215), hinge 1-15 (216- 230), CH2 N84.4>Q (297) (231-340), CH3 D12 (356),L14 (358) (341-445), CHS (446-447)) (118-447)], (220-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-10*01 (84.8%) - IGKJ2*01 (91.7%) L124>V (108)/Homo sapiens IGKV4-1*01 (80.2%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated
Структура
Иностранные названия
- Briquilimabum (латинское)
- Briquilimab (английское)
- Briquilimab (немецкое)
- Briquilimab (французское)
- Briquilimab (испанское)
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