Булумтатуг фуведотин

Prop. INN (наименование, предложенное ВОЗ)

2862919-82-0

immunoglobulin G1-kappa, anti-[Homo sapiens NECTIN4 (nectin-4, nectin cell adhesion molecule 4, PVRL4, poliovirus receptor-related 4, PPR4, LNIR)], conjugated on an average of 8 cysteinyl residues to monomethylauristatin E (MMAE), with a ratio of 1 to 4, via a cleavable divalent linker;
H-gamma1 heavy chain (1-449) [VH Musmus/Homsap (Mus musculus IGHV2-6-5*01 (78.4%) -(IGHD) -IGHJ3*01 (91.7%) A128>S (119)/Homo sapiens IGHV4-4*08 (78.4%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-220')-disulfide with L-kappa light chain (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (91.1%) -IGKJ4*01 (91.7%), CDR-IMGT [12.3.9] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')]; dimer (228-228'':231-231'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of eight l-cysteinyl residues on an average among 222, 228, 231, 220', 222'', 228'', 231'' and 220''' with four divalent groups consisting of (1Z)-3-{[(2S,3R,6R,7R,8²S,11R,12S,15S,18S,26S,29S)-12-[(2S)-butan-2-yl]-26-[3-(carbamoylamino)propyl]-43²,43⁶-difluoro-2-hydroxy-7,11-dimethoxy-3,6,13,19-tetramethyl-5,9,14,17,20,25,28,31-octaoxo-15,18,29-tri(propan-2-yl)-21,33,36,39,42-pentaoxa-4,13,16,19,24,27,30-heptaaza-8(2,1)-pyrrolidina-1,43(1),23(1,4)-tribenzenatritetracontaphan-43⁴-yl]amino}-1-carboxy-3-oxoprop-1-ene-1,2-diyl (fuvedotin)

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