Каботамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

immunoglobulin VH-G1CH1h-G4CH2CH3-scFv_L-kappa dimer, anti-[Homo sapiens CDH17 (cadherin 17)], anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], humanized monoclonal antibody, bispecific;
VH-G1CH1h-G4CH2CH3-scFv fused heavy chain humanized (1-697) [VH-G1CH1h-G4CH2CH3) heavy chain anti-CDH17 humanized (1-446) [(VH (Homo sapiens IGHV3-23*04 (89.7%) -(IGHD) -IGHJ4*01 (91.7%) S128>A (116), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03 (100%) G1m3 CH1-h, CH1 R120 (CH1 R120 (213) (117-214), hinge 1-15 (215-229)) (117-229) -Homo sapiens IGHG4*01 CH2-CH3, nG4m(a) CH2 L92, G4v1 CH2 L1.3 (CH2 F1.3>L (233), L92 (308) (230-339), CH3 (340-444), CHS (445-446)) (230-446) -7-mer (prolyl-alanyl-tetraglycyl-seryl) linker (447-453) -scFv heavy-kappa anti-CD3E humanized (454-697) [(VH (Homo sapiens IGHV3-66*01 (76.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.15] (479-486.504-511.550-564)) (454-575) -15-mer tris(tetraglycyl-seryl) linker (576-590) -V-KAPPA (Homo sapiens IGKV1-NL1*01 (88.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (617-622.640-642.679-687)) (591-697)]], (219-214')-disulfide with kappa light chain anti-CDH17 humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (83.2%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153'), V101 (191') (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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