Кадонилимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

DB16680

2394841-59-7

immunoglobulin G1-kappa anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], each heavy chain being fused to a scFv anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte-associated protein 4, CD152)], monoclonal antibody, bispecific, tetravalent;
gamma1 heavy chain anti-PDCD1 fused to scFv anti-CTLA4 (1-713) [gamma-1 heavy chain (1-448) [VH anti-PDCD1 (Homo sapiens IGHV3-23*04 (88.7%) -(IGHD) -IGHJ6*01 (90.9%) T123>L (113)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 L1.3>A (235), L1.2>A (236), G1>A (238) (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)] -20-mer tetrakis(tetraglycyl-seryl) linker (449-468) -scFv heavy-lambda anti-CTLA4 (469-713) [VH anti-CTLA4 G49>C (512) (Homo sapiens IGHV1-2*02 (84.7%) -(IGHD) -IGHJ5*01 (90.9%) S128>A (583)) CDR-IMGT [8.8.8] (494-501.519-526.565-572) (469-583) -20-mer tetrakis(tetraglycyl-seryl) linker (584-603) -V-LAMBDA anti-CTLA4 (Homo sapiens IGLV7-46*01 (85.3%) -IGLJ3*02 (91.7%) G120>C (705)) CDR-IMGT [9.3.9] (629-637.655-657.694-702) (604-713)]];
(221-214')-disulfide with kappa light chain anti-PDCD1 (1'-214') [V-KAPPA (Mus musculus IGKV14-111*01 (86.3%) -IGKJ5*01 (100%)/Homo sapiens IGKV1-16*01 (80.0%) -IGKJ2*01 (81.8%) Q120>A (100), I126>L (106)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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