Калотатуг гинистинаг

Prop. INN (наименование, предложенное ВОЗ)

2847102-44-5

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], Homo sapiens monoclonal antibody, conjugated on 8 cysteinyl residues to a STING agonist, with a ratio of 1 to 8;
H-gamma1 heavy chain Homo sapiens (1-446) [VH (Homo sapiens IGHV3-48*01 (100%) -(IGHD) -IGHJ2*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 D12 (356), L14 (358) (341-445), CHS K2>del (446)) (118-446)], (220-215')-disulfide with L-kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (97.9%) -IGKJ4*01 (100%), CDR-IMGT [7.3.9] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa; substituted at the sulfur atom of eight l-cysteinyl residues at position 220, 226, 229, 215', 220'', 226'', 229'' and 215''' with radical group (3RS)-1-[(4S,47S,53S,54R,55R,56R)-4-[(15S)-20-{[(6E)-4⁶,9⁵-dicarbamoyl-1⁴,12⁴-diethyl-1²,12²-dimethyl-2,11-dioxo-3,10-diaza-1,12(5)-bis[1,3]oxazola-4(2,3)-imidazo[4,5-b]pyridina-9(1,2)-[1,3]benzimidazoladodecaphan-6-en-9⁷-yl]oxy}-15-methyl-3,13,16-trioxo-7,10,17-trioxa-4,14-diazaicosan-1-yl]-53,54,55,56,57-pentahydroxy-2,5,8,11,14,17,45,50-octaoxo-47-{[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl}-21,24,27,30,33,36,39,42-octaoxa-3,6,9,12,15,18,46,51-octaazaheptapentacontan-1-yl]-2,5-dioxopyrrolidin-3-yl (ginistinag)

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