Кантузумаб мертансин
Cantuzumab mertansineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
400010-39-1
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens MUC1 sialylated carbohydrate, tumour-associated (CA242, cancer antigen 242)], humanized monoclonal antibody conjugated to maytansinoid DM1;
gamma1 heavy chain (1-449) [humanized VH (Homo sapiens IGHV7-4-1*02 (76.50%) -(IGHD)-IGHJ2*01 R120>Q (111), L123>T (114)) [8.8.12] (1-119) - Homo sapiens IGHG1*01 (120-449)], (222-219')-disulfide with kappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV2-28*01 (82.00%) -IGKJ3*01 V124>L (109), D125>E (110), I126>L (111)) [11.3.9] (1'-112') -Homo sapiens IGKC*01 (113'-219')]; (228-228":231-231")- bisdisulfide dimer; conjugated, on an average of 4 lysyl, to maytansinoid DM1 [N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine] via the reductible SPP linker [N-succinimidyl 4-(2-pyridyldithio)pentanoate]
gamma1 heavy chain (1-449) [humanized VH (Homo sapiens IGHV7-4-1*02 (76.50%) -(IGHD)-IGHJ2*01 R120>Q (111), L123>T (114)) [8.8.12] (1-119) - Homo sapiens IGHG1*01 (120-449)], (222-219')-disulfide with kappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV2-28*01 (82.00%) -IGKJ3*01 V124>L (109), D125>E (110), I126>L (111)) [11.3.9] (1'-112') -Homo sapiens IGKC*01 (113'-219')]; (228-228":231-231")- bisdisulfide dimer; conjugated, on an average of 4 lysyl, to maytansinoid DM1 [N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine] via the reductible SPP linker [N-succinimidyl 4-(2-pyridyldithio)pentanoate]
Химическая формула
DMI C35H48CIN3O10S
Структура
Иностранные названия
- Cantuzumabum mertansinum (латинское)
- Cantuzumab mertansine (английское)
- Cantuzumab mertansine (французское)
- Cantuzumab mertansina (испанское)
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