Цемавафусп

Rec. INN (наименование, зарегистрированное ВОЗ)

2711705-98-3

enterobacteria phage H19B L-methionyl-Shiga-like toxin 1 subunit A1 (SLT-1 subunit A1, SLT-1a1, verotoxin 1 subunit A1, verocytotoxin 1 subunit A1, EC:3.2.2.22) (2-252), variant (S⁴⁵>I⁴⁶, V⁵⁴>I⁵⁵, R⁵⁵>L⁵⁶, I⁵⁷>F⁵⁸, P⁵⁹>F⁶⁰, E⁶⁰>T⁶¹, E⁶¹>L⁶², G¹¹⁰>A¹¹¹, R¹⁸⁸>A¹⁸⁹, C²⁴²>S²⁴³, R²⁴⁸>A²⁴⁹, R²⁵¹>A²⁵²) fused via the peptide linker ²⁵³EFPKPSTPPGSSGGAP²⁶⁸ to an anti-(human programmed cell death 1 ligand 1 (PD-L1, CD274)) murine immunoglobulin single chain variable fragment (scFv) (269-501) containing the heavy chain variable region (VH) region (269-390), a ³⁹¹GGGGS³⁹⁵ peptide linker and the light chain variable region (VL) region (396-501) fused via peptide linker ⁵⁰²HHAA⁵⁰⁵ to an HLA-A*02 immunodominant MHC class I restricted epitope derived from human cytomegalovirus (CMV) pp65 (UL83) protein (506-514), disulfide bridged dimer, produced in Escherichia coli; human scFv dimer monoclonal antibody fusion with human SLTA and MHC-I antigen; antigen: human programmed cell death 1 ligand 1, PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1 (CD274); fusion protein (Shiga-like toxin 1, Escherichia coli subunit A1): 1-251 (ins1M T46I V55I R56L I58F P60F E61T E62L G111A R189A C243S R249A, R252A); linker: 252-268; type: Fv-heavy scFv; VH: 269-390; HV germline: Homo sapiens IGHV1-2*02; HJ germline: Homo sapiens IGHJ4*01; CDR Kabat H1: EYTMH (299-303); CDR Kabat H2: GINPNNGGTWYNQKFKG (318-334); CDR Kabat H3: PYYYGSREDYFDY (367-379); linker: 391-395; Type: Fv-kappa scFv; light chain class: kappa; LV germline: Homo sapiens IGKV1-39*01; LJ germline: Homo sapiens IGKJ2*01; VL: 396-501; CDR Kabat L1: SASSSVSYMY (419-428); CDR Kabat L2: LTSNLAS (444-450); CDR Kabat L3: QQWSSNPPT (483-491); Linker: 502-505; fusion protein: 506-514 (major histocompatibility complex I HLA-A*02-restricted epitope, derived from human cytomegalovirus viral tegument protein UL83/pp65)

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