Цергутузумаб амуналейкин

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB14874

1509916-03-3

immunoglobulin G1-kappa fused to IL2 (interleukin 2), anti- [Homo sapiens CEACAM5 (carcinoembryonic antigenrelated cell adhesion molecule 5, CEA, CD66e)], humanized monoclonal antibody fused to IL2;
gamma1 heavy chain (1-451) [humanized VH (Homo sapiens IGHV1-18*01 (82.70%) -(IGHD)-IGHJ6*01) [8.8.14] (1-121) -Homo sapiens IGHG1*01, G1m17,1 (CH1 (122-219), hinge (220-234), CH2 L1.3>A (238), L1.2>A (239), P114>G (333) (235-344), CH3 Y5>C (353), T22>S (370), L24>A (372), Y86>V (411) (345-449), CHS (450- 451)) (122-451)], (224-215')-disulfide with kappa light chain (1’-215’) [humanized V-KAPPA (Homo sapiens IGKV1- 16*01 (82.10%) -IGKJ2*01) [6.3.10] (1'-108') -Homo sapiens IGKC*01, Km3 (109'-215')]; gamma1 heavy chain fused to IL2 (1''-598'') [humanized VH (Homo sapiens IGHV1-18*01 (82.70%) -(IGHD)-IGHJ6*01) [8.8.14] (1''- 121'') -Homo sapiens IGHG1*01, G1m17,1 (CH1 (122''- 219''), hinge (220''-234''), CH2 L1.3>A (238''), L1.2>A (239''), P114>G (333'') (235''-344''), CH3 S10>C (358''), T22>W (370''), (345''-449''), CHS K2>del (450'')) (122''- 450'') -15-mer (tris(tetraglycyl-seryl)) linker (451''-465'') - Homo sapiens IL2 (Pr21-153) T23>A (468''), F62>A (507''), Y65>A (510''), L92>G (547''), C145>A (590'') (466''-598'')], (224''-215''')-disulfide with kappa light chain (1'''-215''') [humanized V-KAPPA (Homo sapiens IGKV1-16*01 (82.10%) -IGKJ2*01) [6.3.10] (1'''-108''') -Homo sapiens IGKC*01, Km3 (109'''-215''')]; dimer (230-230":233-233")- bisdisulfide

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