Цетуксимаб бета
Cetuximab betaМНН
Prop. INN (наименование, предложенное ВОЗ)
CAS
205923-56-4
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], chimeric monoclonal antibody;
H-gamma1 heavy chain chimeric (1-449) [VH (Mus musculus IGHV2-2*03 (93.8%) -(IGHD) -IGHJ3*01 (100%)), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-214’)-disulfide with L-kappa light chain chimeric (1’-214’) [V-KAPPA (Mus musculus IGKV5-48*01 (95.8%) -IGKJ5*01 (100%)), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1’-107’) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (228-228":231-231")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform beta
H-gamma1 heavy chain chimeric (1-449) [VH (Mus musculus IGHV2-2*03 (93.8%) -(IGHD) -IGHJ3*01 (100%)), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-214’)-disulfide with L-kappa light chain chimeric (1’-214’) [V-KAPPA (Mus musculus IGKV5-48*01 (95.8%) -IGKJ5*01 (100%)), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1’-107’) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (228-228":231-231")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform beta
Структура
Иностранные названия
- Cetuximabum beta (латинское)
- Cetuximab beta (английское)
- Cetuximab beta (немецкое)
- Cétuximab bêta (французское)
- Cetuximab beta (испанское)
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