Циботерцепт

Rec. INN (наименование, зарегистрированное ВОЗ)

2769700-97-0

human activin receptor type 2-B (activin receptor type IIB, ACTR-IIB) extracellular domain (ECD) fragment (2-116, 1- 115 in the current sequence), engineered variant (S¹>del, I¹¹>L, L²⁷>V, Q³⁴>K, ⁵⁰TI⁵¹>SL, L⁵³>I, ⁶⁹QE⁷⁰>DT, E⁷⁵>K, F⁸⁹>M) fused via the peptide linker ¹¹⁶GGG¹¹⁸ to a human immunoglobulin G1 Fc fragment (h-CH2-CH3-CHS domains [Homo sapiens IGHG1*01 (hinge (119-128), CH2 (129-238), CH3 (239-343), CHS K³⁴⁵>del (344-344))]) (119-344), disulfide bridged homodimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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