Цилгавимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

DB16393

2420563-99-9

immunoglobulin G1-kappa, anti-[Homo sapiens severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-461) [VH (Homo sapiens IGHV3-15*01 (96.0%) -(IGHD) - IGHJ4*01 (100%)) CDR-IMGT [8.10.22] (26-33.51-60.99-120) (1-131) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v21 CH2 Y15.1, T16, E18, G1v39 CH2 F1.3, E1.2, S116 (CH1 R120 (228) (132-229), hinge 1-15 (230-244), CH2 L1.3>F (248), L1.2>E (249), M15.1>Y (266), S16>T (268), T18>E (270), P116>S (345) (245-354), CH3 E12 (370), M14 (372) (355-459), CHS (460-461)) (132-461)], (234-219')-disulfide with kappa light chain Homo sapiens (1’-219’) [V-KAPPA (Homo sapiens IGKV4-1*01 (96.0%) -IGKJ4*01 (100%)) CDR-IMGT [12.3.8] (27-38.56-58.95-102) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (240-240":243-243")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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