Циреветмаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2473240-98-9

immunoglobulin G2-kappa, anti-[Canis lupus familiaris TGFB1 (transforming growth factor beta1, TGF beta)], caninized monoclonal antibody;
gamma2 heavy chain caninized (1-452) [VH (Canis lupus familiaris IGHV1-30*01 (88.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Canis lupus familiaris IGHG2*01, G2v1 A1.3, A1.2, A1 (CH1 (118-214), hinge 1-19 (215-233), CH2 M1.3>A (237), L1.2>A (238), G1>A (240) (234-343), CH3 (344-450), CHS (451-452)) (118-452)], (132-213')-disulfide with kappa light chain caninized (1'-213') [V-KAPPA (Canis lupus familiaris IGKV3-18*02 (83.5%) -IGKJ3*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Canis lupus familiaris IGKC*01 (100%) (108'-213')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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