Цитатузумаб богатокс

Rec. INN (наименование, зарегистрированное ВОЗ)

945228-49-9

immunoglobulin Fab fusion protein, anti-[Homo sapiens tumorassociated calcium signal transducer 1 (TACSTD1, gastrointestinal tumor-associated protein 2, GA733-2, epithelial glycoprotein 2, EGP2, epithelial cell adhesion molecule Ep-CAM, KSA, KS1/4 antigen, M4S, tumor antigen 17-1A, CD326)], humanized Fab fused with Bougainvillea spectabilis Willd rRNA N-glycosidase [type I ribosome inactivating protein (RIP), bouganin], VB6-845; gamma1 heavy chain fragment (1-225) [hexahistidyl (1-6) -humanized VH from 4D5MOC-B (Homo sapiens FR/Mus musculus CDR, Homo sapiens IGHJ4*01, V124>L) [8.8.9] (7-122) -Homo sapiens IGHG1*01 CH1-hinge fragment EPKSC (123-225)], (225-219')-disulfide with kappa fusion chain (1'-481') [humanized V-KAPPA from clone 4D5MOC-B (Homo sapiens FR/Mus musculus CDR, Homo sapiens IGKJ1*01, I126>L) [11.3.9] (1'-112') -Homo sapiens IGKC*01 (113'-219') -12-mer furin linker (proteolytic cleavage spacer from Pseudomonas exotoxin A) (220'-231') -Bougainvillea spectabilis Willd bouganin fragment (27-276 from precursor, V354'>A, D358'>A, Y364'>N, I383'>A) (232'- 481')]

C₃₄₅₅H₅₃₇₁N₉₂₁O₁₀₆₀S₁₈

77348,44 г/моль

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