Колтуксимаб равтансин
Coltuximab ravtansineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB06342
CAS
1269764-99-9
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)], chimeric monoclonal antibody conjugated to maytansinoid DM4;
gamma1 heavy chain (1-450) [Mus musculus VH (IGHV1-69*02 - (IGHD)-IGHJ4*01) [8.8.13] (1-120) -Homo sapiens IGHG1*01 (CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-211')-disulfide with kappa light chain (1'- 211') [Mus musculus V-KAPPA (IGKV4-70*01 -IGKJ1*01) [5.3.7] (1'- 104') -Homo sapiens IGKC*01 (105'-211')]; dimer (229-229'':232- 232'')-bisdisulfide; conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM4 [N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine] via the reducible SPDB linker [N-succinimidyl 4-(2-pyridyldithio)butanoate]
gamma1 heavy chain (1-450) [Mus musculus VH (IGHV1-69*02 - (IGHD)-IGHJ4*01) [8.8.13] (1-120) -Homo sapiens IGHG1*01 (CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-211')-disulfide with kappa light chain (1'- 211') [Mus musculus V-KAPPA (IGKV4-70*01 -IGKJ1*01) [5.3.7] (1'- 104') -Homo sapiens IGKC*01 (105'-211')]; dimer (229-229'':232- 232'')-bisdisulfide; conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM4 [N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine] via the reducible SPDB linker [N-succinimidyl 4-(2-pyridyldithio)butanoate]
Структура
Иностранные названия
- Coltuximabum ravtansinum (латинское)
- Coltuximab ravtansine (английское)
- Coltuximab ravtansin (немецкое)
- Coltuximab ravtansine (французское)
- Coltuximab ravtansina (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Колтуксимаб равтансин: