Комекибарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2833673-47-3

immunoglobulin G4-kappa, anti-[Homo sapiens IL4R (interleukin 4 receptor, IL4RA, IL-4RA, interleukin 13 receptor, CD124)], humanized monoclonal antibody;
H-gamma4 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-48*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v24 CH3 L107, S114 (CH1 (123-220), hinge 1-12 S10>P (230) (221-232), CH2 L92 (311) (233-342), CH3 M107>L (430), N114>S (436) (343-447), CHS K2>del (448)) (123-448)], (136-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (89.5%) -IGKJ2*02 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-114')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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