Комсалеуцел

Prop. INN (наименование, предложенное ВОЗ)

human culture expanded activated autologous tumour- infiltrating lymphocytes (TIL) isolated from cervical cancer tissue. The cells are mechanically and enzymatically isolated from resected tumour biopsy of patients and cultured in serum-free media containing recombinant interleukin 2 (IL-2). The cells are activated in serum-free media using anti-CD3 antibody, IL-2 and then further expanded in the presence of irradiated allogeneic peripheral-blood mononuclear cells (PBMCs) derived from healthy donors. The T lymphocytes (>90% CD45+CD3+) are a heterogeneous mixture of CD4+ and CD8+ TILs predominantly with effector memory, central memory and effector cell subsets, and a low level of CD45+CD3-CD56+ natural killer (NK) cells (0-10%). The T-lymphocytes demonstrate cytolytic activity and secrete cytokines in a co-culture-based assay

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