Копрелотамаб
CoprelotamabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16380
CAS
2348469-84-9
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosineprotein kinase erbB-2, EGFR2, HER2, HER-2, p185cerbB2, NEU, CD340)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-450) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain humanized (1’-214’) [V-KAPPA humanized (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')];
dimer (229-229":232-232")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-DG44 cell line, glycoform alfa
gamma1 heavy chain humanized (1-450) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain humanized (1’-214’) [V-KAPPA humanized (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')];
dimer (229-229":232-232")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-DG44 cell line, glycoform alfa
Структура
Иностранные названия
- Coprelotamabum (латинское)
- Coprelotamab (английское)
- Coprelotamab (немецкое)
- Coprélotamab (французское)
- Coprelotamab (испанское)
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